Brown ground chuck and diced onion in a large skillet.

Drain excess fat.

Add tomato juice, tomato paste, Italian seasoning, garlic powder, salt, pepper, and pepperoni to the skillet.

Simmer the sauce over medium heat until it thickens, approximately 30-45 minutes.

While the sauce simmers, cook lasagna noodles according to package directions.

Drain the cooked noodles and rinse with cold water to prevent sticking.

In a large baking dish, layer the noodles, meat sauce, cottage cheese, mozzarella cheese, and parmesan cheese.

Repeat layers until all ingredients are used, ending with a layer of mozzarella and parmesan cheese on top.

Bake in a preheated oven at 375°F (190°C) for 30-40 minutes, or until bubbly and golden brown.

Let stand for 10 minutes before cutting and serving.