Preheat broiler and line a baking pan with aluminum foil. Spray with cooking spray.

Combine Greek yogurt, mayonnaise, lime juice, red onion, rice vinegar, cilantro, hot sauce, salt, and ancho chile powder in a bowl.

Stir in shredded cabbage to make the slaw.

Place tilapia fillets on the prepared baking pan.

Squeeze lime juice over the fish.

Combine cumin, paprika, salt, and garlic powder in another bowl.

Sprinkle spice mixture over the fish.

Broil until fish flakes easily with a fork, about 8-10 minutes.

Warm flour tortillas in the microwave between damp paper towels for 1-2 minutes.

Spoon the cooked tilapia onto each tortilla and top with the slaw.

Serve immediately.